Another way to die: autophagic programmed cell death
Top Cited Papers
- 25 October 2005
- journal article
- review article
- Published by Springer Nature in Cell Death & Differentiation
- Vol. 12 (S2) , 1528-1534
- https://doi.org/10.1038/sj.cdd.4401777
Abstract
Programmed cell death (PCD) is one of the important terminal paths for the cells of metazoans, and is involved in a variety of biological events that include morphogenesis, maintenance of tissue homeostasis, and elimination of harmful cells. Dysfunction of PCD leads to various diseases in humans, including cancer and several degenerative diseases. Apoptosis is not the only form of PCD. Recent studies have provided evidence that there is another mechanism of PCD, which is associated with the appearance of autophagosomes and depends on autophagy proteins. This form of cell death most likely corresponds to a process that has been morphologically defined as autophagic PCD. The present review summarizes recent experimental evidence about autophagic PCD and discusses some aspects of this form of cell death, including the mechanisms that may distinguish autophagic death from the process of autophagy involved in cell survival.Keywords
This publication has 35 references indexed in Scilit:
- Escape of Intracellular Shigella from AutophagyScience, 2005
- Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected MacrophagesCell, 2004
- Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genesNature Cell Biology, 2004
- Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8Science, 2004
- Autophagy in Yeast: A Review of the Molecular Machinery.Cell Structure and Function, 2002
- Autophagosome Formation in Mammalian Cells.Cell Structure and Function, 2002
- The autophagosomal–lysosomal compartment in programmed cell deathCell Death & Differentiation, 2001
- Molecular dissection of autophagy: two ubiquitin-like systemsNature Reviews Molecular Cell Biology, 2001
- The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple TissuesMolecular Cell, 2000
- The morphology of various types of cell death in prenatal tissuesTeratology, 1973