HYPOTENSIVE EFFECTS OF PENTOBARBITAL AND DIURETICS ON SYMPATHECTOMIZED SPONTANEOUSLY HYPERTENSIVE RATS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 226  (1) , 149-155
Abstract
The upper abdominal sympathetic chain with the splanchnic nerve was removed bilaterally in spontaneously hypertensive rats (Okamoto-Aoki). After operative recovery, the sympathectomized spontaneously hypertensive rats were as hypertensive as intact or sham operated ones. Anesthesia with pentobarbital or administration of diuretics [hydrochlorthiazide] induced a significantly greater fall of pressure in the sympathectomized hypertensive rats. The hypotensive effect of either drug was insignificant or considerably small, if present at all, in sympathectomized normotensive control rats. In intact spontaneously hypertensive rats, the hypotensive effects of pentobarbital and diuretics appear to be compensated for by a reflex activation of the abdominal sympathetic nerves.

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