ANALGESIC EFFECT OF INTRATHECHAL KETAMINE IN RATS

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Abstract
The analgesic effect of ketamine hydrochloride 200,400, 800 and 1600 μg kg−1, administered intrathecally in rats, was evaluated using the tail-flick test. A short-lived analgesic effect was demonstrated with the larger doses and this could be abolished by pretreatment with naloxone hydrochloride 200 μg kg−1. Intrathecal morphine 100 μg kg−1 produced a more profound analgesic effect than intrathecal ketamine 1600 μg kg−1. There were three deaths shortly after intrathecal injection of ketamine. Histopathological examination of the spinal cords and nerve roots of these rats revealed the presence of vacuoles in the cells of the posterior root ganglion. Other rats sacrificed for histopathological examination showed no changes attributed to the injectate.

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