Direct fractionation procedure for hydrogen peroxide-acetic acid oxidation products from aromatic amines by reversed-phase liquid chromatography.

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Abstract
In order to eliminate the tedious, multi-step isolation process commonly used in the synthesis of aromatic amine oxides employing hydrogen peroxide and acetic acid, a direct chromatographic fractionation procedure was developed. The polar reagents were found to be flushed out, while the N-oxide was retained by a reversed-phase column packed with styrene-divinylbenzene copolymer gel or octadecylsilanized silica gel as the stationary phase, and using methanol-water as the mobile phase. By stepwise elution, clean-up of the reagents and direct fractionation of the N-oxide from the crude reaction mixture were simultaneously accomplished.

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