LH-RH TESTING IN MEN WITH DOWN'S SYNDROME

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Abstract
Males with Down''s syndrome frequently present incomplete sexual development and are presumed to be sterile. The intent of this study is to clarify the etiology of diminished sexual function in men with trisomy 21. Single dose LH-RH [luteinizing hormone releasing hormone] stimulation tests were performed in 6 men with Down''s syndrome. Compared to a control group of 6 mentally retarded, institutionalized males, the subjects with Down''s syndrome had markedly elevated basal FSH [follicle stimulating hormone] and slightly elevated LH [luteinizing hormone] concentrations. The FSH response to LH-RH stimulation was notably increased in the Down''s syndrome group, while the LH response showed a lesser increase. Testosterone concentrations were comparable in the 2 groups. The results are consistent with the clinical assumption that males with Down''s syndrome have decreased spermatogenesis and infertility and that their Leydig cell function is less affected.

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