High-resolution optical tomographic imaging of soft biological tissues

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Abstract
Optical Coherence tomography is a recently developed imaging technique that has potential to improve the diagnostic limits of the currently available imaging techniques, allowing wide range of clinical disorders to be addressed at an early stage. We report in this paper the application of our OCT system to image soft biological tissues with resolution approaching 9 microns. The tissue targets include biological species, the rat and human G.I. tract tissues. For the G.I. tract tissues, both the normal and pathological specimens, including oesophagus, stomach and colon were imaged. Sharp differentiation of structures and features was observed. The images acquired in this study provide information on tissue microstructure that could only previously be obtained with conventional excisional biopsy.

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