Isolation of 2(Antho-RWamide II), a novel neuropeptide from sea anemones

Abstract
Using a radioimmunoassay for the peptide sequence Arg‐Phe‐NH2 (RFamide), a novel peptide has been purified from acetic acid extracts of the sea anemone Anthopleura elegantissima. This peptide has the structure 2, and was named Antho‐RWamide II. Antho‐RWamide II is a neuropeptide. Its structure is closely related to an earlier characterized neuropeptide from Anthopleura 2 (Antho‐RWamide I).