beta-Endorphin induces nonconvulsive limbic seizures.
- 1 October 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (10) , 5221-5225
- https://doi.org/10.1073/pnas.75.10.5221
Abstract
The endogenous opioid peptide, .beta.-endorphin, induces nonconvulsive limbic epileptiform activity when administered intraventricularly to rats. Epileptiform activity is elicited by .beta.-endorphin in doses that are devoid of analgesic or behavioral signs. Equimolar intraventricular doses of morphine or of the enkephalin analog [DAla2,Met5]enkephalin-NH2 fail to elicit this limbic epileptiform activity. These observations, together with the recent immunohistochemical localization of .beta.-endorphin to midline limbic structures, suggest that .beta.-endorphin may have an important role in the regulation of limbic excitability.This publication has 28 references indexed in Scilit:
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