Enhancement of T Cell MLR Reactivity by Addition of Macrophage Supernatants from Tumor-Bearing Mice

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Abstract
One-way mixed lymphocyte reactions (MLR) were used to establish a correlation between loss of in vitro T [thymus-derived] cell reactivity and in vivo tumor growth. Though supernatants from anti-Thy 1 treated macrophages (M.PHI.) greatly enhanced MLR activity in normal T cells, such addition had little effect in reversing the inability of T cells from 2 wk palpable tumor-bearing mice (TBM) to recognize in vitro foreign histocompatibility antigens. Since normal T cells, exposed to TBM M.PHI. supernatants, exhibited no decrease in proliferative response, TBM T cell loss of MLR reactivity could not be ascribed to tumor-induced suppressor M.PHI.