LETHAL AND SUBLETHAL EFFECTS OF HYDROXYUREA IN RELATION TO DRUG CONCENTRATION AND DURATION OF DRUG EXPOSURE IN SARCOMA- 180 INVITRO
- 1 January 1977
- journal article
- research article
- Vol. 37 (8) , 2628-2637
Abstract
The lethal and sublethal effects of hydroxyurea were studied in [mouse] sarcoma 180 in vitro in relation to drug concentration and drug exposure duration using cloning methods, radioautography and flow microfluorometry. Postperturbation changes in radioautographic labeling intensity reflected real changes in the rate of DNA synthesis in individual cells. The data suggest that the lethal and sublethal effects of hydroxyurea are dependent on the rate of DNA synthesis. These findings have important implications for the interpretation of DNA content distributions under perturbation conditions and the development of drug treatment regimens that are based on cell kinetics.This publication has 11 references indexed in Scilit:
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