Dose response for blood pressure and degree of cardiac beta-blockade with atenolol
Open Access
- 1 August 1979
- journal article
- clinical trial
- Published by Oxford University Press (OUP)
- Vol. 55 (646) , 537-540
- https://doi.org/10.1136/pgmj.55.646.537
Abstract
Summary: The hypotensive effect of 25 mg, 50 mg, 75 mg, 100 mg and 0 mg of atenolol daily were compared in a double-blind within-patient study. The fall in blood pressure with 25 mg daily was not significantly different than with 100 mg. The dose response curve lies between 0 and 25 mg daily. Cardiac beta-blockade (measured by suppression of exercise tachycardia) was not maximal with 25 mg of atenolol daily. The dose response curves for beta-blockade and the hypotensive effect are not parallel.Keywords
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