ROLE OF CELL LOCOMOTION IN LYMPHOCYTE MIGRATION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 36  (2) , 247-255
Abstract
The role of cell locomotion in lymphocyte traffic was investigated following the in vivo fate of 51Cr labeled [mouse] lymph node cells pretreated in vitro with substances known to modify cell motility. Lymphocyte migration is an energy dependent process, as it could be impaired by sodium azide. It requires the integrity of microfilaments, as it was modified by Cytochalasin B. It is altered by isoproterenol, theophylline, prostaglandin E1 and dibutyryl cyclic-AMP. The relevance of these findings to the process of lymphocyte recirculation was discussed.