INFLUENCE OF PREVIOUS IMMUNIZATION ON SKIN GRAFT SURVIVAL

Publisher Website
Google Scholar
Abstract
The results of skin grafts transplanted in immunized and nonimmunized recipients was analyzed. Specific sensitization for HLA-A or B determinants shortened graft survival if the recipients were immunized by s.c. injections of leukocytes. When the recipients had been pregnant, no such influence of specific HLA-A or B sensitization could be demonstrated. The variance in mean survival times of grafts exchanged between mixed lymphocyte culture (MLC)-positive donor-recipient combinations was significantly smaller than the variance in mean survival time (MST) of grafts exchanged between MLC-negative combinations. This may be the result of the influence of allograft immune-activating determinants of different strength in the MLC-negative donor-recipient combinations. The variance in MST of grafts in immunized recipients was significantly larger than the variance in MST of grafts in nonimmunized recipients. Apart from the obvious effect of HLA-A and B sensitization, other factors must have influenced graft survival. No evidence for a graft enhancing effect of B [bone marrow-derived] cell-specific antibodies was found.

This publication has 0 references indexed in Scilit: