Effect of Chemotherapy on Growth in the Skeletally Immature Individual

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Abstract
Fortunately, it is no longer unusual for a child to survive cancer and live into adulthood. Particular success has been seen with the sarcomas since the widespread use of multiagent adjuvant chemotherapy in the 1970s. Interest may now be focused on long-term sequelae of both the disease and its treatment. Numerous published reports deal with the long-term outcome of skeletal growth in survivors of childhood cancer [1–3,5–7,9,13,14]. However, these reports deal primarily with survivors of leukemia and central nervous system tumors. In most cases, the children studied have received radiation therapy to the brain or vertebrae which exerts a particular local influence on skeletal growth.