Localization of the fibroblast growth factor receptor‐4 gene to chromosome region 5q33‐qter
- 1 January 1992
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 4 (1) , 94-98
- https://doi.org/10.1002/gcc.2870040116
Abstract
Our polymerase chain reaction cloning of novel tyrosine kinases expressed in the K562 chronic myeloid leukemia cells has revealed a novel fibroblast growth factor receptor, FGFR4. We have here mapped the FGFR4 gene by analysis of somatic cell hybrids and in situ hybridization to the 5q33-qter chromosomal region. This finding is of interest in that the FGFR4 gene is expressed in several leukemia cell lines and the 5q33-qter region is involved in nonrandom chromosomal translocations in acute myelogenous leukemias and Ki- I lymphomas.Keywords
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