Itraconazole
- 1 January 2000
- journal article
- review article
- Published by Taylor & Francis in Expert Opinion on Pharmacotherapy
- Vol. 1 (2) , 287-304
- https://doi.org/10.1517/14656566.1.2.287
Abstract
Itraconazole is a broad spectrum triazole antifungal agent. It has favourable pharmacodynamic and pharmacokinetic profiles and is available as both oral and iv. formulations. Over the last two decades, clinical and animal infection studies have demonstrated the efficacy of itraconazole in a wide range of superficial fungal infections including difficult-to-treat dermatophytoses and onychomycoses. Furthermore, shortened treatment regimens have proven to be effective, ranging from 1-day treatment for vaginal candidosis to 1-week pulse therapy per month, for 2 - 4 months, in onychomycosis and follicular dermatophytosis. Clinical experience with itraconazole in the treatment of deep mycoses is less comprehensive. However, results in systemic candidosis, sporotrichosis, blastomycosis, paracoccidioiodomycosis, certain types of histoplasmosis and aspergillosis are extremely encouraging. Itraconazole is less effective in the treatment of chromomycosis and coccidioidomycosis. Nevertheless, considering the refracto...Keywords
This publication has 90 references indexed in Scilit:
- Pharmacoeconomic Analysis of Oral Antifungal Therapies Used to Treat Dermatophyte Onychomycosis of the ToenailsPharmacoEconomics, 1998
- Itraconazole pulse therapy for onychomycosis and dermatomycoses: An overviewJournal of the American Academy of Dermatology, 1997
- Itraconazole for the treatment of tinea pedis: A dosage of 400 mg/day given for 1 week is similar in efficacy to 100 or 200 mg/day given for 2 to 4 weeksJournal of the American Academy of Dermatology, 1997
- Treatment and Prophylaxis of Tinea InfectionsDrugs, 1996
- Present and potential diagnostic techniques in onychomycosisJournal of the American Academy of Dermatology, 1996
- Itraconazole interacts with felodipineJournal of the American Academy of Dermatology, 1995
- Kinetics and spectrum of activity of oral antifungals: The therapeutic implicationsJournal of the American Academy of Dermatology, 1993
- Posttreatment itraconazole levels in the nailJournal of the American Academy of Dermatology, 1992
- Itraconazole in the treatment of tinea capitisJournal of the American Academy of Dermatology, 1990
- Pharmacokinetic profile of orally administered itraconazole in human skinJournal of the American Academy of Dermatology, 1988