Cyanogen Bromide-Induced Chemical Ligation: Mechanism and Optimization of the Reaction Conditions
- 1 June 1996
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 15 (6) , 1137-1147
- https://doi.org/10.1080/07328319608007382
Abstract
Chemical ligation induced by BrCN in the presence of N-substituted morpholine has been studied in details. It has also been shown that the phosphate activation by BrCN can be used for the synthesis of nucleotide derivatives in aqueous solutions.Keywords
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