DIRECT DELIVERY OF ANTI-CANCER AGENTS - EXPERIMENTAL TREATMENT OF INTRA-OCULAR MALIGNANCY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 17  (10) , 993-1004
Abstract
Two anticancer agents, one lipophilic, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), and one hydrophilic, 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DTIC), were used to treat Brown-Pearce epithelioma in the anterior chamber of rabbit eyes. The BCNU test animals were divided into 3 groups: 1 treat by direct injection of the drug into the subconjunctival space or the anterior chamber, the 2nd by both direct injection and i.v. administration and the 3rd by i.v. injection alone. The DTIC test animals were treated with only local injection into the subconjunctival space or anterior chamber. Dosage, delivery system and effectiveness were compared following clinical observation and histopathologic examination. Direct delivery of BCNU or DTIC in subconjunctival space or anterior chamber delayed the growth of Brown-Pearce epithelioma in rabbit eye. The effectiveness of this treatment was significantly enhanced by combining direct injection with systemic administration of a lower dose of BCNU.