Development of an Anticonvulsant Agent Based on its Effect on γ-Aminobutyric Acid Metabolism

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Abstract
The administration of isonicotinic acid hydrazide (2.2 mmol/kg) plus pyridoxine (4.4 mmol/kg) to chicks 14–18 h prior to exposure to hyperbaric oxygen provided excellent protection against the onset of oxygen-induced seizures in the birds.

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