Association of HLA–Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the “shared epitope” hypothesis
- 1 January 1991
- journal article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 34 (1) , 43-47
- https://doi.org/10.1002/art.1780340107
Abstract
Rheumatoid arthritis (RA) is prevalent in Yakima Indians, a Native American tribe. HLA–DR4, the HLA specificity commonly associated with RA in Caucasians, is rare among the Yakima. Using a specific oligonucleotide probe that recognizes DR4 nucleotide sequences associated with RA, a rare HLA–Dw16 gene was identified in 83% of Yakima patients with RA and in 60% of Yakima control subjects. This shared sequence encodes a discrete class II epitope that is highly correlated with RA in both DR4 positive and DR4 negative individuals.Keywords
This publication has 15 references indexed in Scilit:
- HLA Genes associated with rheumatoid Arthritis. Identification of susceptibility alleles using specific oligonucleotide probesArthritis & Rheumatism, 1989
- Sequence analysis of the HLA-DRß and HLA-DQß loci from three Pemphigus vulgaris patientsHuman Immunology, 1988
- A specific nucleotide sequence defines a functional T-cell recognition epitope shared by diverse HLA-DR specificitiesHuman Immunology, 1988
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988
- The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritisArthritis & Rheumatism, 1987
- IDENTIFICATION OF HLA-Dw14 GENES IN DR4+ RHEUMATOID ARTHRITISThe Lancet, 1986
- Molecular diversity of HLA-DR4 haplotypes.Proceedings of the National Academy of Sciences, 1986
- HLA and Disease AssociationsPublished by Springer Nature ,1985
- Association of the B-Cell Alloantigen DRw4 with Rheumatoid ArthritisNew England Journal of Medicine, 1978
- High prevalence of rheumatoid arthritis in yakima indiansArthritis & Rheumatism, 1973