Changes Produced by Kanamycin: Early Histologic Manifestations in the Inner Ears of Cats

1 August 1962

journal article
other
Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery

Vol. 76 (2) , 146-150
https://doi.org/10.1001/archotol.1962.00740050152008

Abstract

Since the discovery of kanamycin in 1957,¹this antibiotic has been used clinically in conditions often treated with streptomycin or neomycin. Histopathologic evidence of ototoxicity^2-6similar to that seen from streptomycin and neomycin, and a lack of cochlear microphonic response and of Cr. VIII nerve action potentials²have been reported in kanamycin toxicity. Comparison of cochlear microphonics between kanamycin-damaged and dihydrostreptomycin-damaged ears showed a much greater depression of response in patients demonstrating kanamycin in the serum 24 hours after the original injection. The histopathological changes reported were atrophy of the organ of Corti and a reduction of spiral ganglion cell population. Kanamycin B was found to be much more toxic than the original kanamycin.²Typical concentrations of kanamycin used by previous investigators are as follows: Hawkins: 50 mg. per kilogram for 75 days; 200 mg. per kilogram for 30, 50, 70, 75 days. Owada: 250 mg.

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