Augmented Accumbal Serotonin Levels Decrease the Preference for a Morphine Associated Environment During Withdrawal
- 1 January 2001
- journal article
- Published by Springer Nature in Neuropsychopharmacology
- Vol. 24 (1) , 75-85
- https://doi.org/10.1016/s0893-133x(00)00184-6
Abstract
Recent studies have found that acute morphine administration increases serotonin (5-HT) transmission within the nucleus accumbens and other forebrain regions. In contrast, 5-HT transmission is depressed during withdrawal from chronic morphine. We show that pharmacological agents that increase brain 5-HT levels (fluoxetine or 5-hydoxytryptophan, 5-HTP) abolish the preference of chronically morphine-treated, withdrawn rats for a morphine-associated environment. Similar results were seen when fluoxetine was microinjected into the nucleus accumbens. Conversely, rats given morphine acutely showed an enhanced preference for a morphine-associated environment when pretreated with these agents. Fluoxetine also decreased the heightened anxiety found in morphine withdrawn rats. The results of our study indicate that drugs that augment 5-HT levels may reduce the desire for morphine during withdrawal.Keywords
This publication has 0 references indexed in Scilit: