Plant Antimutagens, 6. Intricatin and Intricatinol, New Antimutagenic Homoisoflavonoids from Hoffmanosseggia intricata
- 1 July 1989
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 52 (4) , 774-778
- https://doi.org/10.1021/np50064a018
Abstract
Intricatin [1] and intricatinol [2] are new homoisoflavonoids isolated from a desert plant Hoffmanseggia intricata, which was collected in Baja California, Mexico. The structures of the compounds were elucidated using a variety of spectroscopic techniques. The structure of 1 was shown to be 7,4''-dimethoxy-8-hydroxyhomoisoflavone, and 2 was shown to be 4''-methoxy-7,8-dihydroxyhomoisoflavone. Both compounds 1 and 2 displayed activity in the inhibition of the mutagenicity of 2AN toward Salmonella typhimurium (T98). Compound 2 was much more active than 1 in the case of the inhibition of the mutagenicity of AAF toward S. typhimurium (T98) and the inhibition of EMS towards S. typhimurium (T100). Compounds 1 and 2 are the first examples of antimutagenic activity in homoisoflavones.This publication has 1 reference indexed in Scilit:
- Peltogynoids and homoisoflavonoids from Caesalpinia pulcherrimaPhytochemistry, 1983