The influence of myelosuppression on the response to chemotherapy in small cell bronchogenic carcinoma
- 1 August 1984
- Vol. 54 (3) , 411-415
- https://doi.org/10.1002/1097-0142(19840801)54:3<411::aid-cncr2820540307>3.0.co;2-5
Abstract
In an attempt to clarify the relationship between myelosuppression and the response to chemotherapy, 127 cases of small cell lung cancer were reviewed. These patients received a total of four different drug combinations. The myelosuppression of the first chemotherapy course was reduced with the addition of one or two drugs to the basic Cytoxan (cyclophosphamide)-vincristine drug combination without a change in the incidence of remission. Patients with good performance status have less severe leukopenia and thrombocytopenia than those with poor performance status. Patients with complete and partial response have slightly more severe thrombocytopenia but not leukopenia than the nonresponders. It is concluded that the burden of tumor has a direct effect on the incidence of remission and myelosuppression suggesting that more severe toxicity is necessary to obtain remission in poor risk patients. Myelosuppression is required before assessing whether the patient has received an adequate amount of chemotherapeutic agent but is only a weak prognostic factor.This publication has 11 references indexed in Scilit:
- Serum cyclophosphamide activity in patients treated for small cell carcinoma of the lung.Journal of Clinical Oncology, 1983
- Chemoimmunotherapy of small cell bronchogenic carcinomaCancer, 1978
- INTENSIVE CHEMOTHERAPY OF SMALL CELL BRONCHOGENIC CARCINOMA1977
- HOW STRONG IS THE CASE FOR INTENSIVE CANCER CHEMOTHERAPY?The Lancet, 1976
- Burkitt's lymphoma in Ibadan: Response to various doses of cyclophosphamide and long-term survivorsPublished by Elsevier ,1976
- CYCLOPHOSPHAMIDE AND CCNU IN TREATMENT OF INOPERABLE SMALL CELL-CARCINOMA AND ADENOCARCINOMA OF LUNG1976
- Characteristics of prognosis and response to an imidazole carboxamide in malignant melanomaClinical Pharmacology & Therapeutics, 1971
- Pharmacokinetics of cyclophosphamide in manBritish Journal of Pharmacology, 1971
- Activation of cyclophosphamide in man and animalsCancer, 1971
- STUDIES ON THE MANAGEMENT OF MOUSE LEUKEMIA (L1210) WITH ANTAGONISTS OF FOLIC ACID1955