Production of Neurogenic Afferent Renal Vasoconstriction in Humans and Dogs by 2-Benzyl-4, 5-Imidazoline HCl (Priscoline)

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Abstract
After the intraven. admn. of Priscoline in normal humans and dogs there is an immediate and marked decrease in renal plasma flow and glomerular filtration rate. This effect is not secondary to changes in systemic arterial pressure. Priscoline does not alter the renal extraction ratios of para-aminohippurate. Tubular dysfunction and intrarenal shunts are therefore not implicated in the action of the drug. Calculation of the renal resistances reveals the presence of afferent arteriolar constriction. These effects are mediated neurogenically since they are not seen in the denervated kidney. The effects of Priscoline on renal dynamics in the normal human and exptl. animal are discussed in terms of renal circulatory physiology and exptl. hypertension. In dogs splenic contraction with resultant rise in hematocrit, follows the injn. of Priscoline. Evidence from normal humans and dogs fails to support the clinical use of Priscoline in the therapy of "lower nephron nephrosis" or other types of anuria.