Prednisone in the Treatment of Rheumatoid Arthritis

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Abstract
THE new adrenocortical steroid prednisone1 was used in the treatment of 33 patients with rheumatoid arthritis.Prednisone and the related steroid prednisolone have been shown to possess a high degree of adrenocortical activity2 and to be highly effective clinically as antirheumatic and inflammatory agents.3 4 5 So far, in addition to rheumatoid arthritis and allied conditions, certain allergic disorders,6 bronchial asthma6 7 8 9 and pemphigus vulgaris10 have been reported to respond. Bunim et al.,11 studying the metabolic effects of prednisone and prednisolone, observed no retention of sodium or increased loss of potassium as a result of their administration. Although the drugs are three or . . .