Metabolism of low-dose paracetamol in patients with rheumatoid arthritis

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Abstract
1. Low dose (500 mg) paracetamol (acetaminophen) was administered to patients with rheumatoid arthritis (RA) and to age-matched healthy controls and to hospital controls. 2. At this dose level, patients with RA excreted decreased amounts of paracetamol sulphate (controls means 11.3.5 3. The mean ratio of excretion of paracetamol sulphate/paracetamol glucuronide was 5.6.12.1, 5.3. 10.7 in controls but 2.1.2.7 in RA patients (P<0-001). 4. Patients with RA appear to have less capacity for excreting paracetamol as non-toxic conjugates and may be more susceptible to paracetamol toxicity, especially on chronic dosage. 1, 10.6. 5.9; RA mean 3.02.3.7). This difference is statistically significant (P< 0.001).