Direct Electrochemical Measurement of Nitric Oxide Production by Cytochrome P450-catalyzed Oxidation of N,N′-Substituted Hydroxyguanidines
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Analytical Communications
- Vol. 34 (2) , 69-71
- https://doi.org/10.1039/a608091j
Abstract
The production of nitric oxide by oxidative cleavage of N- hydroxyguanidines catalyzed by rat liver microsomes was measured directly, and for the first time by differential-pulse amperometry at a Nafion–porphyrin coated micro-sensor. The measured concentration of the nitric oxide produced (0.18–0.25 µM) was lower than the total concentration of the stored nitrites. The difference in the obtained data is discussed.Keywords
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