Towards tumour targeting with copper-radiolabelled macrocycle–antibody conjugates
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 12,p. 792-794
- https://doi.org/10.1039/c39890000792
Abstract
Tetra-aza-macrocycles covalently attached to a monoclonal antibody may be efficiently radiolabelled with 64Cu or 67Cu at pH 4, minimising non-specific binding to the protein, giving a kinetically stable conjugate in vivo.Keywords
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