BIOGENESIS OF VARIOTIN

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Abstract
DL-Glutamic acid-2-14C and DL-glutamic acid-3, 4-14C were definitely incorporated into the molecule of variotin, when labeled glutamic acid was introduced into the culture of Paecilomyces varioti in the early period of variotin production and the culture was harvested after the production reached the maximal level. The radioactivity was observed to be mainly localized in the γ-aminobutyric acid moiety, suggesting that glutamic acid might be a fairly direct precursor of the moiety. By the method employed, DL-glutamic acid-1-14C was not significantly incorporated into variotin. It was demonstrated that L-glutamic acid was converted to γ-aminobutyric acid in the presence of acetone-dried cells of Paecilomyces varioti. These results indicated that decarboxylation of glutamic acid was involved in the formation of variotin. The incorporation yield was decreased when DL-glutamic acid-3, 4-14C was introduced into the culture in the late stage of variotin formation.

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