1-Indancarboxylic acids. III. Chemical modifications of antiinflammatory 4-aroyl-1-indancarboxylic acids.

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Abstract
For elucidating the receptor site of antiinflammatory arylacetic acids, some modifications were made on 4-aroy-1-indancarboxylic acids (I) which have potent antiinflammatory activities. Modifications were introduced on the characteristic parts of I and 1-methylated derivatives, tetralin analogs and benzyl analogs of I were prepared. These compounds showed weaker activities than the parent compound I. 1-Indancarboxylic acid is the pharmacologically effective derivative of arylacetic acid.