Comparative pharmacokinetics of ceftizoxime and other third-generation cephalosporins in humans

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Abstract
The pharmacokinetic parameters of ceftizoxime were determined in ten patients undergoing myelography. Each patient received 30 mg/kg of ceftizoxime intravenously over 8 to 15 min. The pharmacokinetic parameters were calculated by standard methods. The T ½ α was 0.34 ± 10.65 min. The T ½ β was 56 ± 13 min. Total body clearance and volume of distribution were 156 ± 74 ml/min and 0.153 ± 0.062 l/kg, respectively. Data in this study provided T ½ shorter than those generally found in the literature in which the T ½ β normally is 1.3 to 1.6 h. Drug was not detected in the CSF in these individuals because the sensitivity of the assay was only 1 mg/l and none of the individuals had meningeal inflammation.

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