THE EFFECT OF HYDROCORTISONE AND PROGESTERONE ON THE ELECTROLYTE ACTION EXHIBITED BY DESOXYCORTICOSTERONE IN THE ADRENALECTOMIZED RAT1

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Abstract
The influence of hydrocortisone and progesterone on the action of desoxycorticosterone (DOC) on sodium and potassium excretion was investigated in adrenalectomized rats. Hydrocortisone at low levels facilitated sodium excretion and at all levels tested facilitated potassium excretion. Progesterone did not elicit any effect on electrocute excretion. When administered concomitantly with DOC, increasing dosages of hydrocortisone and progesterone induced sodium excretion even in the presence of DOC. By comparison of dosages hydrocortisone was shown to be 40 times as active as progesterone in bringing about 50% block of DOC effect. The simultaneous administration of DOC and hydrocortisone produced an increased excretion of potassium; this effect was not observed when DOC and progesterone were administered concomitantly.