PROGNOSTIC-SIGNIFICANCE OF RENAL ANGIITIS IN SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE)

  • 1 January 1983
    • journal article
    • research article
    • Vol. 20  (3) , 109-113
Abstract
Cases (80) of SLE [systemic lupus erythematosus] with renal involvement wer analyzed. Angiitis involving arterioles and interlobular arteries was observed in 17 of 42 cases with diffuse proliferative lupus GN [glomerulonephritis]. This was not observed in other types of lupus GN. Of 17 cases of angiitis, 7 were complicated by thrombosis. Irregular deposits of Ig and complement were demonstrated in vessel walls and luminal thrombi and suggested an immune-complex origin. Fibrinogen was frequently demonstrable. Vascular lesions were associated with severe glomerular and tubulointerstitial injury and poor prognosis. A relatively favorable outcome was observed in SLE without renal angiitis.

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