Paranatal Complications Are Not Associated with Affective Disorders in the Offspring of Bipolar Manic-Depressives

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Abstract
The pregnancy and birth records of 55 of 58 adult offspring of 17 bipolar manic-depressives were obtained. All but 3 of the subjects had been previously interviewed to ascertain the prevalence of psychiatric disorders. Paranatal complications and affective disorders appeared to be distributed independent of each other within this population. The presence of paranatal complications did not enhance the risk of affective disorders in this population, nor did they bring their onset forward in time.

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