Anticancer titanium agents

Publisher Website
Google Scholar
Abstract
Most antitumour Ti compounds act on tumours in the gastrointestinal tract. Some species with increased water solubility also show activity towards breast, lung and melanoma cancers. These compounds are structurally and chemically diverse, ranging from complex salts to coordination complexes. In the former, the oxidative state can be either Ti(III) or Ti(IV); while in the latter the co-ordination number can be 4 or 6. Active 6 coordinate species can be mono- or tetranuclear compounds. This review focuses on recent progress in this promising area including clinical studies and their related patents. Additional features of this non-toxic metal, not yet described in patents, are also mentioned along with perspectives for application in cancer therapy.