A chronic myeloproliferative disorder associated with monosomy 7 in the bone marrow cells; normal karyotype in acute transformation

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Abstract
A chronic myeloproliferative disorder associated with monosomy 7 of the bone marrow cells is described in a male infant. After nearly 4 yr, during which time no drug therapy was given, the disease transformed to a blast crisis and at this stage the karyotypes of the marrow and unstimulated blood cells were shown to be normal. The development of the myeloproliferative disorder associated with monosomy 7 is a multistage process and the acquisition of the chromosomal abnormality is a secondary event.