Prevalence of factor V Leiden mutation in various populations
- 1 January 1997
- journal article
- research article
- Published by Wiley in Genetic Epidemiology
- Vol. 14 (4) , 403-411
- https://doi.org/10.1002/(sici)1098-2272(1997)14:4<403::aid-gepi5>3.0.co;2-3
Abstract
Resistance to activated protein C (APC) is the most common inherited risk factor for venous thrombosis. Most cases of APC resistance are caused by the point mutation nt 1691 G–A in factor V gene, referred to as factor V Leiden mutation. As initially shown in a Dutch population, this mutation has a carrier rate of 2.9%, the most frequent genetic disposition for thrombophilia and deep venous thrombosis. By large‐scale epidemiological studies we have determined the prevalence of factor V Leiden mutation in populations from Poland (200), Argentina (215), Venezuela (126), Costa Rica (196), and India (150). The prevalences have been estimated for Poland (Warsaw) 5.0%, Argentina (Buenos Aires) 5.1%, Venezuela (Valencia) 1.6%, Costa Rica (San José) 2.0%, and India (Punjab) 1.3%. Based on worldwide distribution, it can be hypothesized that the factor V Leiden mutation has originated and accumulated in central European Caucasians and spread over the world by migration. Genet. Epidemiol. 14:403–411,1997.Keywords
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