A Fast Method for Testing Covariates in Population PK/PD Models
- 2 July 2011
- journal article
- Published by Springer Nature in The AAPS Journal
- Vol. 13 (3) , 464-72
- https://doi.org/10.1208/s12248-011-9289-2
Abstract
The development of covariate models within the population modeling program like NONMEM is generally a time-consuming and non-trivial task. In this study, a fast procedure to approximate the change in...Keywords
This publication has 15 references indexed in Scilit:
- The use of clinical irrelevance criteria in covariate model building with application to dofetilide pharmacokinetic dataJournal of Pharmacokinetics and Pharmacodynamics, 2008
- Models for Plasma Glucose, HbA1c, and Hemoglobin Interrelationships in Patients with Type 2 Diabetes Following Tesaglitazar TreatmentClinical Pharmacology & Therapeutics, 2008
- Population Pharmacokinetic-Pharmacodynamic Model for Neutropenia with Patient Subgroup Identification: Comparison across Anticancer DrugsClinical Cancer Research, 2006
- PsN-Toolkit—A collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEMComputer Methods and Programs in Biomedicine, 2005
- Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer.Journal of Clinical Oncology, 1998
- Automated Covariate Model Building Within NONMEMPharmaceutical Research, 1998
- Assumption Testing in Population Pharmacokinetic Models: Illustrated with an Analysis of Moxonidine Data from Congestive Heart Failure PatientsJournal of Pharmacokinetics and Biopharmaceutics, 1998
- The importance of modeling interoccasion variability in population pharmacokinetic analysesJournal of Pharmacokinetics and Biopharmaceutics, 1993
- Building population pharmacokineticpharmacodynamic models. I. Models for covariate effectsJournal of Pharmacokinetics and Biopharmaceutics, 1992
- A three-step approach combining bayesian regression and NONMEM population analysis: Application to midazolamJournal of Pharmacokinetics and Biopharmaceutics, 1991