Pulmonary Veno-Occlusive Disease in the Middle-Aged

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Abstract
Pulmonary venoocclusive disease (PVO) is an uncommon cause of pulmonary hypertension which is difficult to diagnose without histology. We report 3 cases of histologically confirmed PVO. These patients were all middle-aged or older, and 1 had spontaneous improvement in his symptoms. PVO may occur more commonly among older adults than previously believed and indolent forms of the disease may exist. As new therapeutic approaches to the various entities causing pulmonary hypertension were developed; it is increasingly important to determine precisely which condition is present in a given patient.

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