Hepatic metabolism of vitamin D3 in streptozotocin-induced diabetic rat

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Abstract
The effect of streptozotocin-induced diabetes on the in vitro conversion of vitamin D3 to 25-hydroxyvitamin D3 by isolated liver microsomes from rachitic rats was examined. Enzymic activity was significantly less than that observed in control animals (P < 0.001). Insulin administration restored activity almost to control values. Diabetes in this animal model apparently produces alterations in vitamin D metabolism.

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