An efficient and flexible route to (+)-polyoxamic acid using diastereoselective epoxidation of 1-arylthio-1-nitroalkenes
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 1,p. 95-96
- https://doi.org/10.1039/c39940000095
Abstract
Polyoxamic acid 4a is prepared by a short and efficient process in which the key steps are the highly diastereoselective nucleophilic epoxidation of the D-threitol-derived alkene 6 using potassium tert-butylperoxide, followed by reaction of the oxirane 7a with ammonia.Keywords
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