Ovarian Cancer, Oral Contraceptives, andBRCAMutations
- 6 December 2001
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 345 (23) , 1706-1707
- https://doi.org/10.1056/nejm200112063452312
Abstract
Modan and colleagues (July 26 issue)1 conclude that oral contraceptives do not protect against ovarian cancer in Israeli Jewish women carrying BRCA mutations. We have shown, in two studies of Jewish and non-Jewish women with BRCA mutations, that the use of oral contraceptives was strongly protective against ovarian cancer.2,3 In our recent study, the odds ratio for ovarian cancer among women who had used oral contraceptives was 0.44 (95 percent confidence interval, 0.28 to 0.68).3Keywords
This publication has 5 references indexed in Scilit:
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- Tubal ligation and risk of ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control studyThe Lancet, 2001
- Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian CancerAmerican Journal of Human Genetics, 2001
- BRCA1 and BRCA2 Mutation Analysis of 208 Ashkenazi Jewish Women with Ovarian CancerAmerican Journal of Human Genetics, 2000
- Oral Contraceptives and the Risk of Hereditary Ovarian CancerNew England Journal of Medicine, 1998