Specificity of Antineoplastic Phenomenon Induced in Mice by Carcinogenic Agents

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Abstract
When mice were inoculated with 3 carcinogenic compounds, they developed a transient antineoplastic (AN) response which was demonstrable by tissue culture technique. This AN phenomenon appeared to be chemically and genetically specific. Duration of the AN response to the 3 agents may represent the latent period of carcinogenesis, since the An phenomenon disappeared when the tumor emerged. The interpretation of the AN phenomenon on an immunological basis is discussed.

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