Adrenal, Pituitary and Urinary Ascorbic Acid Levels in Rats Subjected to Hypothermic Environment

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Abstract
Adult male albino rats were placed in metabolism cages and maintained at common laboratory temp. or in the cold (2-4[degree] C). When the animals were killed in their respective environments 1, 3, 10, 12 or 28 days later, the adrenal and pituitary glands were weighed and analyzed for ascorbic acid. It was found that following the 1-day period both adrenal wt. and ascorbic acid content were greater in the cold-stressed rats. The amt. of pituitary vit. C was found to be significantly lower than control values at the 1-day interval, about normal at 10 days and greatly elevated at the 28th day. Results of the analyses for urinary ascorbic acid show that the rats in the cold excreted about the same amt. in a 24-hr. period as did the controls.

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