Relationship of Estrogen and Vitamin K.

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Abstract
Estradiol injection into male rats kept on a Vit. K-free diet was effective in lowering plasma prothrombin time to normal values in 6 hours. This Vit. K-like activity was observed even at a dosage of 20 μg/rat. Conversely, testosterone administration (1 mg/rat) to female rats significantly increased plasma prothrombin time as compared to untreated controls.