PHARMACOKINETICS OF FLUORESCEIN IN THE VITREOUS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 21  (4) , 542-549
Abstract
The pharmacokinetics of fluorescein in the vitreous after i.v. or oral fluorescein administration was studied in normal individuals. Vitreous and free blood fluorescein concentrations were measured over an 8 h period by fluorophotometry and fluorescence polarization. A computer model was constructed based on the free plasma fluorescein concentrations and conformed closely to the experimental data. The concentration profiles of fluorescein appearance in the vitreous were then examined. The effect of alterations in retinal permeability and free blood fluorescein concentrations were also discussed. An increase in the concentration of fluorescein in the vitreous as measured by fluorophotometry can be caused by factors other than an increase in blood-retinal barrier permeability.