Analysis of serial radionuclide bone images in osteosarcoma and breast carcinoma.

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Abstract
The use of the Kaplan-Meier actuarial technique for serial diagnostic studies is described. They then present an analysis of previously published data on the results of serial radionuclide bone images in patients with osteosarcoma or breast carcinoma, using this technique. Patients with osteosarcoma show an almost instar increase in the occurrence of bone metastases 5-29 mo. after diagnosis; the rate is approximately 1%/mo. Patients with breast cancer show a biphasic rate of development, averaging only 0.5%/mo. during the 1st yr after diagnosis but increasing rapidly to approximately 2%/mo. after 15 mo.

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