THE RELATIONSHIP BETWEEN DIFFERENTIAL PRESSURE AND BLOOD FLOW IN A CORONARY ARTERY

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Abstract
The moment to moment rate of flow into coronary arteries was measured while the vessels were perfused under relatively constant heads of pressure. Comparison of the rate of blood flow into a coronary artery with the differential pressure (between the perfusion and peripheral coronary pressures) shows that: the peripheral coronary pressures indicate the exact time relations of the changes of resistance to flow in the coronary arteries; the systolic and diastolic values of these curves correctly represent the heads of pressure that will just not cause inflow of blood during the respective periods of the cardiac cycle; and the differential pressure curves represent the direction and roughly the magnitude of the phasic changes of coronary flow but underestimate the exact value of the moment to moment coronary flow. The curves obtained indicate that under normal conditions the intramural blood flow will show a sudden retardation with the onset of isometric contraction, during systole forward flow will persists in most hearts, with the onset of isometric relaxation forward flow will rapidly increase and will remain rapid during the latter part of diastole, diminishing slightly with the decline of the head of pressure in the aorta.

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