Dominant transplantation tolerance impairs CD8+ T cell function but not expansion
- 4 November 2002
- journal article
- Published by Springer Nature in Nature Immunology
- Vol. 3 (12) , 1208-1213
- https://doi.org/10.1038/ni853
Abstract
Alloreactive CD8+ T cells may persist in animals made tolerant of transplanted tissues; their function is controlled through continuous censorship by regulatory CD4+ T cells. We sought to establish the stage at which such censorship operates. We found that monospecific CD8+ T cells introduced into tolerant animals responded to the tolerated tissue antigen as if they had received CD4+ T cell "help": they proliferated and accumulated normally. However, they did show compromised graft rejection, interferon-gamma production and cell-mediated cytotoxicity. These findings suggest that tolerance mediated by regulatory T cells acts by censoring immune effector functions rather than by limiting the induction of T cell responsesKeywords
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